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1-Tissue Compartment Model (Alpert)

This model is intended to calculate the parameters of a 1-tissue compartment model. It is just a slightly modified version of the classical implementation of Alpert's time-weighted integral approach for brain perfusion.

There are two changes:

  1. The parameters are expressed as K1, k2, and Vt (rather than f, f/p, p).
  2. Total blood activity can be subtracted for spillover correction.