PKIN Data Processing

General Assumptions in PKIN

The following is generally assumed:

• All loaded data has been decay corrected to the same time point. This means that the PET scanner and the blood sampling times must have been synchronized.
• The input curve C_P(t) represents the authentic ligand in arterial plasma which is available for exchange with tissue.
• The total blood curve C_Blood(t) represents the activity of whole blood.
• A geometrical spillover correction can optionally be performed for the calculation of the operational equation in the form of
  C_Model = vB*C_Blood +(1-vB)*C_Tissue
  where v_B represents the fractional volume of the blood space in the VOI, C_Blood(t) the concentration of all forms of tracer in a sample of blood, and C_Tissue(t) the summed concentrations in all tissue compartments.
• The results of non-cardiac flow models are returned per cm³ tissue. To convert to flow per g tissue the values must be divided by the tissue density.

Exceptions to these rules are specified in the description of the individual models.